Over many years the health benefits of Stolle Wellness products and ingredients have been investigated and reported by a number of respected scientists. The benefits of milk-based ingredients have been demonstrated in many scientific studies. These benefits have been carefully reviewed and form the basis for Stolle Wellness product functional claims of immune support, joint support and muscle recovery.
As noted in the following list of references, scientific studies have also investigated performance in cardio vascular areas. However no functional benefits can be claimed in this until further clinical studies confirm the scientific investigations.
Partial List of Scientific Studies on Milk Based Ingredients:
General
Clare D.A. and Swaisgood H.E. (2000) Bioactive milk peptides: A prospectus. J Dairy Sci 83:1187-1195
Walzem R.M., Dillard C.J., and German J.B. (2002) Whey components: millennia of evolution create functionalities for mammalian nutrition: what we know and what we may be overlooking. Critical Reviews in Food Science and Nutrition 42; 4:353-375.
Gingerich D.A, McPhillips C.M. (2005) Analytical approach to determination of safety of milk ingredients from hyperimmunized cows. Reg Tox Pharm 41:102-112.
Anti-inflammatory Benefits
Goldman, A.S., Thorpe, L.W., Goldblum, R. M. and Hanson, L.A. (1986) Anti-inflammatory Properties of Human Milk. Acta Paediatrica Scandinavica 75:689-695
Ormrod, D.J., Miller, T.E. (1991) The Anti-Inflammatory Activity of a Low Molecular Weight Component Derived from the Milk of Hyperimmunized Cows. Agents and Actions 32:3-4, 160-166.
Ormrod, D.J., Miller T.E. (1992) A low molecular weight component derived from the milk of hyperimmunized cows suppresses inflammation by inhibiting neutrophil emigration. Agents and Actions 37:70-79.
Owens, W.E., Nickerson, S.C., Washburn, P.J. (1992) Effect of a Milk-Derived Factor on the Inflammatory Response to Staphylococcus aureus Intramammary Infection. Veterinary Immunology and Immunopathology 30:2-3, 233-246.
Ormrod D.J., Miller T.E. (1993) Milk from hyperimmunized dairy cows as a source of a novel biological response modifier. Agents and Actions 38. Special Conference Issue C146-C149.
Goldblum, R.M., Goldman, A.S. (1994) Immunological Components of Milk: Formation and Function. Handbook of Mucosal Immunology 643-652.
Stelwagen K., Ormrod D.J. (1998) An anti-inflammatory component derived from milk of hyperimmunized cows reduces tight junction permeability in vitro. Inflamm Res; 47:384-388.
Tai Y.S., Liu B.T., Wang J.T., Sun A., Kwan H.W., Chiang C.P. (2001) Oral administration of milk from cows immunized with human intestinal bacteria leads to significant improvements of symptoms and signs in patients with oral submucous fibrosis. J Oral Pathol Med 30:618-625.
Colker C.M., Swain M.S., Lynch L., Gingerich D.A. (2002) Effects of a milk-based bioactive micronutrient beverage on pain symptoms and activity of adults with osteoarthritis: a double-blind, placebo-controlled clinical evaluation. Nutrition 18:388-392.
Zenk JL, Helmer TR, Kuskowski MA. (2002) The effects of milk protein concentrate on the symptoms of osteoarthritis in adults: an exploratory, randomized, double-blind, placebo-controlled trial. Cur Ther Res 63(7):430-442
Gingerich DA, Strobel JD. (2003) Use of client-specific outcome measures to assess treatment effects in geriatric, arthritic dogs: Controlled clinical evaluation of a nutraceutical. Vet Ther 4(1):56-66.
Immune and GI Health
Ebina, T., Sato, A., Umezu, K., Ishida, N., Ohyama, S., Oizumi, A., Aikawa, K., Katagiri, S., Katsushim, N., Imai, A., Kitaoka, K., Suzuki H, Konno, T. (1985) Prevention of Rotavirus Infection by Oral Administration of Cow Colostrum Containing Anti-human Rotavirus Antibody. Medical Microbiology and Immunology 174:177-185.
Tockman, M.S., Khoury, M.J., Cohen, B.H. (1986) Milk Drinking and Possible Protection of the Respiratory Epithelium. Journal of Chronic Disease 39:3, 207-209.
Michalek, S.M., Gregory, R.L., Harmon, C.C., Katz, J., Richardson, G.J., Hilton, T., Filler, S.J., McGhee J.R (1987) Protection of Gnotobiotic Rats Against Dental Caries by Passive Immunization With Bovine Milk Antibodies to Streptococcus mutans. Infection and Immunity 55:10, 2341-2347.
Tacket, C.O., Losonsky, G., Link, H., Hoang, Y., Guesry, P., Hilpert, H., Levine, M. (1988) Protection by Milk Immunoglobulin Concentrate Against Oral Challenge With Enterotoxigenic Escherichia coli. The New England Journal of Medicine 318:19, 1240-1243.
Filler, S.J., Gregory, R.L., Michalek, S.M., Katz, J., Mcghee, J.R. (1991) Effect of Immune Bovine Milk on Streptococcus-Mutans in Human Dental Plaque. Archives of Oral Biology 36:1, 41-47.
Murosaki, S., Yoshikai, Y., Kubo, C., Ishida, A., Matsuzaki, G., Sato, T., Endo, K., Nomoto, K. (1991) Influence of Intake of Skim Milk from Cows Immunized with Intestinal Bacterial Antigens on Onset of Renal Disease in (NZB X NZW)F1 Mice Fed Ad Libitum or Restricted in Energy Intake. Journal of Nutrition 121:11, 1860-1868.
Ishida, A., Yoshikai, Y., Murosaki, S., Kubo, C., Hidaka, Y. Nomoto, K. (1992) Consumption of Milk from Cows Immunized with Intestinal Bacteria Influences Age-Related Changes in Immune Competence in Mice. Journal of Nutrition 122:9, 1875-1883.
Tacket, C.O., Binion, S.B., Bostwick, E., Losonsky, G., Roy, M.J., Edelman, R. (1992) Efficacy of Bovine Milk Immunoglobulin Concentrate in Preventing Illness After Shigella-flexneri Challenge. American Journal of Tropical Medicine and Hygiene 47:3, 276-283.
Ishida, A., Yoshikai, Y., Murosaki, S., Hidaka, Y., Nomoto, K. (1992) Administration of Milk from Cows Immunized with Intestinal Bacteria Protects Mice from Radiation- Induced Lethality. Biotherapy 5:3, 215-225.
Takahashi N., Eisenhuth, G., Lee, I., Schachtele, C. (1992) Nonspecific Antibacterial Factors in Milk from Cows Immunized with Human Oral Bacterial Pathogens. Journal of Dairy Science. 75: 1810-1820.
Goldblum, R.M., Goldman, A.S. (1994) Immunological Components of Milk: Formation and Function. Handbook of Mucosal Immunology 643-652.
Dial E.J., Romero J.J., Lichtenberger L.M. (1995) Gastroprotection by Dairy Foods Against Stress-Induced Ulcerogenesis in Rats. Digestive Diseases & Sciences 40:11, 2295-2299.
Harmsen, M.C., Swart, P.J., Debethune, M.P., Pauwels R., Declercq E., The, T.H., Meijer, D.K.F. (1995) Antiviral Effects of Plasma and Milk Proteins - Lactoferrin Shows Potent Activity Against Both Human Immunodeficiency Virus and Human Cytomegalovirus Replication In Vitro. Journal of Infectious Diseases 172:2, 380-388.
Korhonen, H., Syvaoja, E.L., Aholaluttila, H., Sivela, S., Kopola, S., Husu, J. (1995) Bactericidal Effect of Bovine Normal and Immune Serum, Colostrum and Milk Against Helicobacter pylori. Journal of Applied Bacteriology 78:6, 655-662.
Kelly C.P., Pothoulakis C., Vavva F., Castagliuolo I., Bostwick E.F., Okeane J.C., Keates S., Lamont J.T. (1996) Anti-Clostridium Difficile Bovine Immunoglobulin Concentrate Inhibits Cytotoxicity and Enterotoxicity of C-Difficile Toxins. Antimicrobial Agents & Chemotherapy 40:2, 373-379.
Losnedahl, K.J., Wang, H., Aslam, M., Zou, S., Hurley, W.L. (1996) Antimicrobial Factors in Milk. Illinois Dairy Report.
Freedman, D.J., Tacket, C.O., Delehanty, A., Maneval, D.R., Nataro, J., Crabb, J.H. (1998) Milk Immunoglobulin with Specific Activity Against Purified Colonization Factor Antigens Can Protect Against Oral Challenge with Enterotoxigenic Escherichia Coli. Journal of Infectious Diseases 177:3, 662-667.
Hattori N, Hata I, Hisakazu I, Mitsuoka T. (2003) Effect of intake of immune milk product on fecal microflora in healthy female volunteers. Bioscience Microflora 22(4):139-144.
Athletic Performance
Bounous G., Molson J. (1999) Competition for glutathione precursors between the immune system and the skeletal muscle: pathogenesis of chronic fatigue syndrome. Med Hypotheses 53:347-349.
Clare D.A. and Swaisgood H.E. (2000) Bioactive milk peptides: A prospectus. J Dairy Sci 83:1187-1195.
Burke D.G., Chilibeck P.D., Davidson K.S., Candow D.G., Farthing J., Smith-Palmer T. (2001) The effect of whey protein supplementation with and without creatine monohydrate combined with resistance training on lean tissue mass and muscle strength. Int J Sport Nutr Exerc Metab 11:349-364.
Cribb P.J., Williams A.D., Hayes A. and Carey M.F. (2002) The effect of whey isolate on strength, body composition and plasma glutamine. Med Sci Sports Exerc. 34 5:A1688.
Middleton N., Jelen P., Bell G. (2004) Whole blood and mononuclear cell glutathione response to dietary whey protein supplementation in sedentary and trained male human subjects. Inter J Food Sci Nutr 55 2:131-141.
Cholesterol & Hypertension
Golay, A., Ferrara, J.M., Felber, J.P. Schneider, H. (1990) Cholesterol-Lowering Effect of Skim Milk from Immunized Cows in Hypercholesterolemic Patients. American Journal of Clinical Nutrition 52:6, 1014-1019.
Sharpe, S.J., Gamble, G.D. Sharpe, D.N. (1994) Cholesterol-Lowering and Blood Pressure Effects of Immune Milk. American Journal of Clinical Nutrition 59:4, 929-934.
Chou H-T, Huang S-C, Ip S-W. (1992) Efficacy and safety of Stolle immune milk in the treatment of mild to moderate essential hypertension. China Medical College, Taichung, Taiwan, R.O.C.
Sharpe, S.J., Gamble, G.D. Sharpe, D.N. (1994) Cholesterol-Lowering and Blood Pressure Effects of Immune Milk. American Journal of Clinical Nutrition 59:4, 929-934.
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